The Purpose of the Financial Policy Essay Example | Topics and Well Written Essays - 1000 words - 21

The Purpose of the Financial Policy - Essay Example Coming to the month of May, the expenses go much down, making the net income to increase, hence an increase in the profit. This shows that the month was not much over-budgeted. On the month of June, the net expenses and deductions increase again drastically. This reduces the net income, in the same way, hence making the net profit be reduced. Even though the company does not realize a loss this month, the profit it gets is so much reduced when compared to the previous month.  Financial policy is criteria or procedure that describes a company’s choices as far as debt/ equity mix, currencies of denomination, maturity structure, the method of financing investment projects, and hedging decisions with a goal of maximizing the value of the firm to a particular group of stockholders.  The purpose of the financial policy is to minimize cost over a long period of time, providing citizens, investors and business owners with confidence when they know that there are strong, and consis tent financial policies in place to guide their businesses.  The benefits of a financial policy include the fact that the stakeholders are guided by certain rules and regulations, hence the gain of confidence in the business over a long period of time. It also enables people to receive payment at the time of service. The financial policy allows one to gain control over a financial system, this enables one to offer financial services to patients while minimizing possible confusions.

CREBP Mutation Schematic Lab Report Example | Topics and Well Written Essays - 2250 words

CREBP Mutation Schematic - Lab Report Example The kinase pathways, in essence, induce phosphorylation of a single residue SER133 (Salks Institute, Undated) on CREB to activate it. There is evidence of four such kinase pathways - cAMP-dependent protein kinase, multiple mitogen-activated protein kinases (MAPKs), ribosome S6 kinase and - and calmodulin-dependent kinases (CAMKs) (Euskirchen, G., et al, 2004). The phosphorylated CREB attracts coactivator CREB binding protein (CBP or CREBBP ) which allows the activated phosphorylated CREB to bind to cAMP-responsive element (CRE) sequences on DNA to initiate gene expression (Thiel, G., et al, 2005). CBP coactivator work is often copied by its paralog p300, a highly related transcriptional coactivator protein targeted by the adenoviral oncoprotein E1A (Brody, T.B., 1996). This is still not a very clear process as much has yet to be known about the mechanism by which CBP binds to the phosphorylated CREB and subsequently promotes gene transcription. For gene transcription to take place a polymerase complex must be recruited, it must then be subsequently isomerized and cleared to transcribe the target gene (Kim, J., et al, 2000). There is evidence that the phsophorylated CREB, after binding with CBP, also recruits a RNA(2) polymerase complex to initiate transcription on CRE elements on target genes in various cells and tissues (Kim, J., et al, 2000). There is much that has been cleared in this direction by the research efforts of Kim et al, 2000, yet more has to be done before any definite conclusions can be reached. The paper now focuses on the molecular and genetic identity of CBP so that the next section on possible mutations on the protein can be better understood. Nevertheless, it is noted here that CREB activity is triggered off by diverse factors such as growth factors, hormones, neurotransmitters, ion fluxes and stress signals (Euskirchen, G., et al, 2004), all of which help recruit the protein. CBP action is initiated through heterodimerization of basic leucine zipper (bZIP) domains (Euskirchen, G., et al, 2004). Its action via gene transcription is also very diverse and the number of genes it helps express is also >100. Thus, mutations in CREBBP or CREB binding protein have numerous implications.The CREB Binding Protein (CBP or CREBBP) CBP is encoded in DNA sequences on human chromosome 16 at 16p13.3 (CREBBP, GeneCard, 2006). Gene location is from GC16M003716 to GC16M003870. The sequence starts at 3,716,568 bp from p terminal and ends at 3,870,723 bp from p terminal making up a sequence of size 154,155 bases with a minus strand orientation (CREBBP, GeneCard, 2006). The human CBP is made up of 2442 amino acid sequences and is 265337 Daltons in molecular weight (CREBBP, GeneCard, 2006). A rough domain count of the protein sequences is available for isoform 'a'. These are as per Table 1 and Diagram 1, Appendix, sourced from Giles et al, 1997, Fig. 3 and 4 respectively. As can be observed from both the table and the diagram, there are 11 distinct domains. This is not exhaustive as there are many regions on the total CREBBP (human) DNA sequence that have not been mapped according to function